(g) Toluidine blue staining of spinal cord sections taken from control and platelet-depleted mice following lysolecithin injection. (hi) Quantification of remyelination finds platelet-depleted mice show significantly less remyelination.

“Circulating Platelets Modulate Oligodendrocyte Progenitor Cell Differentiation During Remyelination.”

Amber R. Philp, et al. – Universidad Austral de Chile.

This study found that transient exposure of oligodendrocyte precursor cells (OPCs) to platelets promoted differentiation into oligodendrocytes, but prolonged exposure inhibited this process. Depletion of platelets impaired remyelination in a lysolecithin mouse model of MS demyelination. Exploring the factors which cause platelets to promote remyelination may provide new therapeutic targets, while the inhibitory factors may be barriers in need of clearing for remyelination to occur.