“Noradrenergic signaling controls Alzheimer’s disease pathology via activation of microglial β2 adrenergic receptors.” Linh Le, et al. – University...
Mechanisms
“Genetic ablation of neuronal mitochondrial calcium uptake halts Alzheimer’s disease progression.” Pooja Jadiya, et al. – Temple University. Background: Mitochondrial...
“Transmembrane protein 97 is a potential synaptic amyloid beta receptor in human Alzheimer’s disease.” Martí Colom-Cadena, et al. –...
“A single-cell atlas of ABCA7 loss-of-function reveals lipid disruptions, mitochondrial dysfunction and DNA damage in neurons.” Djuna von Maydell,...
“Ganglioside Lipids Inhibit the Aggregation of the Alzheimer’s Related Peptide Amyloid-β.” Zenon Toprakcioglu, et al. – University of Cambridge....
September 29th Lipids lost in aging slow amyloid-β fibril formation This study found that gangliosides, membrane lipids whose levels...
“Alzheimer mutations stabilize synaptotoxic γ-secretase-substrate complexes.” Sujan Devkota, et al. – University of Kansas. In this study, Devkota and...
“Neuronal apoE4 induces early hyperexcitability in select populations of hippocampal neurons by altering Nell2 expression.” Sung-Soo Jang, et al....
How does the membrane-bound protease presenilin-1 (PSEN1) function in AD? Three recent preprints consider this question. Harvard researchers found...
“Alzheimer’s disease linked Aβ42 exerts product feedback inhibition on γsecretase impairing downstream cell signaling.” Katarzyna Marta Zoltowska, et al....