Mads Alexander Just Madsen, et al. – Copenhagen University.
In this study, larger cortical lesions in patients with MS were correlated with greater levels of excitatory/inhibitory imbalance, with glutamate levels rising as GABA levels fall. Neurotransmitter differences also varied between MS subtypes; patients with SPMS showed lower levels of glutamate than controls or those with RRMS, while all groups had comparable GABA levels. This study took advantage of 7T MRI for analyzing neurotransmitter levels; on more conventional 3T MRI, lower spectral resolution renders these measurements problematic.
