Implication of DNA methylation changes at chromosome 1q21.1 in the brain pathology of Primary Progressive Multiple Sclerosis.
Majid Pahlevan Kakhki et al., Karolinska Institute
Searching for molecular markers associated with MS diagnosis, this study identified changes at chromosome 1q21.1 linked to PPMS.
– DNA methylation of this region is increased in these patients, both compared to healthy controls and to patients with other types of MS.
– Methylation is associated with patient-specific mutations and decreased expression of nearby genes.
– Reducing methylation of this region could be a new target for therapeutic treatments.
– The identified mutations may prove useful in screening for PPMS risk.
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