Erin Beck, et al. – NINDS.
This study of patients with various MS subtypes found that baseline levels of cortical lesions could predict whether subjects experienced worsening disability by the expanded disability status scale (EDSS), 25-foot timed walk, and 9-hole peg test over the following 2 years. New cortical lesion formation, however, was not correlated with worsening disability over this period, with new cortical lesions being generally rare in patients without new white matter lesions. This suggests that cortical lesion formation early in the disease time course impacts future disease progression, which would further underscore the need for early detection and treatment.
