Andres M. Baraibar, et al. – University of the Basque Country.
This study found that in a mouse model of MS, astrocytes show significant alterations in calcium signaling. These astrocytes show higher baseline calcium activity, weaker calcium responses to cannabinoid signaling, and potentiate associated neural synapses in response to cannabinoids. Since endocannabinoids typically lead astrocytes to weaken these synapses, this shift could contribute to the excitation/inhibition imbalance seen in MS.
