Brittney A. Beyer, et al. – Scripps Research Institute.
This study of drugs already approved for other uses uncovered numerous pairings of compounds that synergistically increased rates of oligodendrocyte progenitor cell differentiation into oligodendrocytes. These combinations focused on pathways that led to the accumulation of 8,9-unsaturated sterols and activation of RXRy. Notably, some of these combinations involve derivatives of vitamin D, supporting recent work that suggests the vitamin’s role in lowering disease risk is tied to its promotion of oligodendrocyte differentiation.
