“Amyloid β Induces Lipid Droplet-Mediated Microglial Dysfunction in Alzheimer’s Disease.”
Priya Prakash, et al. – Purdue University.
This study found that chronic exposure to amyloid β causes murine microglia to accumulate lipid droplets (LDs), with LD+ microglia showing reduced ability to phagocytose amyloid β. In the 5xFAD mouse model of AD, LD+ microglia accumulate with age, especially in female mice. Blocking DGAT2, an enzyme critical for LD formation, restored the ability for microglia from mouse AD models to phagocytose amyloid β, positioning DGAT2 inhibitors as a potential therapeutic in AD.
