“Tau accumulation and its spatial progression across the Alzheimer’s disease spectrum.”
Frédéric St-Onge, et al. – McGill University, Lund University.
In this study, the spread of tau abnormality across brain regions was tracked longitudinally. At a broad level, they confirmed the trajectory outlined by the Braak staging model, progressing from entorhinal cortex to temporal & limbic structures, then to frontal & parietal cortex. On a finer scale, however, there was substantial variability in which portions of these regions accumulate tau, as well as the speed at which tau abnormality spreads across the brain.
