Vahid Gazestani, et al. – Broad Institute of Harvard and MIT.
This study from the lab of Evan Macosko analyzed cortical biopsies collected during surgeries on older adults, providing the opportunity to study early-stage AD without the confounds of post-mortem tissue. They identify a distinct early phase of response to amyloid buildup, characterized by the loss of a Reelin+ inhibitory neuron subtype and hyperactivity in excitatory neurons. They also found that oligodendrocytes are capable of generating amyloid-beta, in addition to excitatory neurons.
